In earlier versions of Windows Server, antivirus settings were only accessible via PowerShell. Now, you can also manage them through the graphical interface: Windows Settings → Windows Security → Virus & threat protection.
If you prefer the command line, open PowerShell as Administrator and run:
Set-MpPreference -DisableRealtimeMonitoring $true.
To re-enable virus and threat protection, run:
Set-MpPreference -DisableRealtimeMonitoring $false.
Both methods—GUI and command line—are fully functional.